Native American Grandmother's Secret Ends Pain... FAST!

Newly discovered inflammation fighter wipes away COX-2, CRP, IL-6 and more...Stops pain and prevents future pain anywhere in your body... Results confiemed in leading medical journals...

See how this all-natural remedy could TRANSFORM your aches, pains and "can't do that's" into comfortable mobility and endless "can do's" - starting in as little as 20 minutes!

Is it possible that Native American healers possessed a pain-relieving secret so powerful it could restore your aching, throbbing, hard-to-move joints back to comfortable flexibility?

Researchers are now saying “Yes!” In fact, this secret actually triggers your body’s natural repair process to help your joints feel brand-new again.

Science published in the journal Mediators of Inflammation, shows that this pain-relieving secret works on a cellular level… to stop pain at its source by stamping down high levels of inflammation.1

Plus, this secret supports every part of your joints – not just cartilage, but also synovial fluid—the fluid that actually lubricates and cushions your joints.

As a result, you'll enjoy healthier joints that are no longer crippled by pain and stiffness, so you can sit, walk, climb and even run with ease.

The best part of this secret?

It starts working so fast that some users report feeling better in as little as 20 minutes!

Finally, you can say “goodbye” to disappointing pain remedies that wear off too quickly. “So long” to prescription drugs that leave you feeling tired and spacey…  and “good riddance” to the worries that your pain will get worse until one day it leaves you laid up permanently.

This natural secret also happens to be a goldmine of vitamins and minerals. That’s why it was both a medicine and a food for Native Americans.

In fact, Native Americans credit this secret from their tribal Grandmother for keeping them strong and healthy for generations.

By ‘grandmother’ I mean something totally different from what you think. In a moment, I’ll explain what Native Americans meant by grandmother and how their secret could free of you pain and stiffness for good!

How can I be so sure?

Because I used to suffer from chronic pain over most of my body. On bad days it was hard to sleep, drive a car, exercise, or even take a walk. Sometimes I could hardly move, and the pain was so bad I would pray for it to stop.

Now, at 63, I have less pain than I had at 40—and most of my days are “good days!”

My name is Lee Euler. I’m Editor-in-Chief of Natural Health Insiders, the newsletter with the mission to uncover today’s most powerful natural solutions so you can live your life to the fullest.

If you’re ready to put an end to chronic pain and stiffness, then you’re going to want to hear this…

It’s the remarkable story of a Native American medicine secret that’s remained virtually unknown to outsiders… and how it can help you forget you ever suffered joint pain.

Imagine how great it will feel to wake up in the morning with little to no stiffness in your body

Imagine the joy of taking long walks, spending an entire day out shopping or enjoying your grandkids without having to sit down – or lie down – to try to recover from the pain…

Imagine the amazement of your family and friends as you move nimbly out of the car and up the stairs ready for your next adventure…

And don’t be surprised if others comment on how happy and healthy you look! As your joints begin to feel more comfortable, you’ll once again take pleasure in everything life has to offer.

Because let’s face it, nothing can darken your life like pain.

Just ask Peggy V. who tried this Native American  medicine secret and said...

“No more stiffness or aching joints! I’m finally able to climb stairs quickly and without pain. I can even get up and down from the floor.”

Or Bob C…

“I had severe knee pain that greatly interfered with my daily life. It definitely took the edge off and the results are longer lasting than other things I’ve tried.”

The relief happens fast. For some people, it’s within 20 minutes. For others, it’s a couple days or weeks. Here’s how it happened for Wendy T…

“My pain disappeared within 2 to 3 days! I prefer using natural remedies. Turmeric, tart cherry juice and enzymes. But this is superior to anything I’ve tried. My joint pain disappeared within two to three days. I’d like to order more.”

So what is this amazing Native American medicine SECRET?

It’s called the aronia berry

…and it’s part of a Native American healing tradition that goes back 13,500 years, perhaps even longer.2

Native Americans believe that man is part of nature and health is a matter of balance. Natural remedies from plants, herbs and roots are used to restore “harmony and balance” to the body…

Sound familiar? Of course it does, because it’s the idea today’s natural medicine was founded upon!

The aronia berry is one of the most important
herbs in the entire Native American
medicine tradition…

In fact, the aronia berry was so important it was often part of a Native American medicine man’s “Grandmother.”

The Grandmother was a bundle that healers carried at all times. It was a portable pharmacy, containing key medicines with the power to nourish and nurture the whole tribe!

Recently, modern science confirmed the power of this Native American remedy. . .

The aronia berry
STOPS PAIN NOW
and PREVENTS
FUTURE PAIN!

As you know, chronic joint pain and inflammation can occur for a number of reasons, including illness, injury and the most common reason of all, age.

But did you know there’s one MAIN CAUSE behind every single ache and pain in your body?

It’s true! I’m talking about INFLAMMATORY CHEMICALS that cause pain in your joints, organs and tissues… inflammatory chemicals like COX-2.

You’ve no doubt heard about this nasty culprit.

COX-2 triggers pain in your body by producing inflammation-causing prostaglandins. Many of the most popular pain relievers on the market work by blocking COX-2.

Trouble is, COX-2 doesn’t act alone. Pain follows a complicated pathway. It starts with gene regulation and cell signaling that results in many different inflammatory chemicals like IL-1, IL-6, CRP and more.

These inflammatory molecules cause pain in your body.

Sadly, most pain relievers can’t address the entire pain process very effectively.  If you let your inflammation and pain go unchecked, then your dull, aching pain that used to come and go will start growing worse and lasting longer … until one day, you’re in pain all the time!

And you’ll find there’s a growing list of things you can’t do easily anymore!

But thanks to this Native American medicine SECRET, you can now block COX-2, and almost all of the other inflammatory chemicals by going straight to the source!

It’s a brand new way to wipe out pain
that works unlike any other natural
remedy or drug available!

The aronia berry’s unique pain-fighting compound works by interrupting the cell signaling mechanisms that trigger inflammation.  This medicine that grows on a bush can restore your joints back to comfort and mobility. 

Now for the first time, the aronia berry is available in TheraFlex ACN. A safe, broad-spectrum solution for chronically painful joints.

Just ask former joint pain sufferers like Pamela H.….

“It worked great! In about two weeks it was easier for me to move”

“It helped to reduce my pain and inflammation in my neck,” says Mike J.…

Pain in my hands and fingers was gone in about a month,” exclaims Joseph B.…

Best of all? Absolutely no side effects! Unlike so many of the over-the-counter pain killers, TheraFlex ACN won’t harm your liver, or any of your other organs.

That’s because the aronia berry works safely WITH your body’s natural repair process so it does NO HARM to your liver like acetaminophen, nor does it hurt your stomach like NSAIDs!

This means you’ll never have to sacrifice your health for the sake of your pain relief. In fact, just the opposite

It can help you grow
stronger and healthier
in virtually every part of your body!

It’s true!

The aronia berry contains almost all known vitamins, including one of the rarest and most important, Vitamin P…

Discovered by Nobel Prize winning scientist Albert Szent-Gyorgyi in 1936, Vitamin P is known today as bioflavonoids. These plant compounds are linked to the healthy function of every cell in your body!3

The Best Herbal Health Newsletter says… “there is no organ in the human body on which the aronia berry does not have a positive influence.”4

A scientific review at Braun School of Public Health declares the aronia berry “one of the most potent natural antioxidants” available.5

And studies published in The Journal of Applied Pharmaceutical Science and Phytotherapy Research show the aronia berry can help repair your entire body.

Early-stage laboratory research suggests the SUPERIOR antioxidant components in aronia can help you:

I think you’ll agree, that’s exactly the kind of pain relief you deserve. Comfortable, easy-to-move joints… and a strong, energetic body! Thanks to TheraFlex ACN...

At long last you can turn that long list of
“can’t do’s” into “yes, I can’s!”

Taking long walks. Playing in the park with your grandkids. Getting back on the golf course or tennis court. Taking those trips you’ve been putting off. . .

Enjoying each day carefree with family and friends sure beats sitting on the sidelines enduring everyone’s concerned glances and daily advice.

If it's still hard to believe that a lifetime of relief is available to you right now…

...then let me give you the hard scientific proof from medicine's most prestigious journals on the aronia berry’s recently discovered pain-fighting compound. It's an antioxidant called anthocyanins or ACNs for short.

ACNs are the most important group of water soluble pigments found in nature. They’re responsible for the beautiful deep blue, purple and red colors of many of nature’s healthiest fruits and vegetables.

Generally speaking, the darker the color of the fruit or vegetable the more ACNs inside.

Now, as someone who knows a thing or two about a healthy diet, you probably know that the more colorful fruits and veggies you consume, the healthier your body. That’s because ACNs are among nature’s most powerful antioxidants! They can scavenge free radicals that cause premature aging and illness like nobody’s business.

But there’s a NEW medical fact about ACNs
that’s so recent, I doubt you’ve heard about it anywhere before…

ACNs STOP pain and inflammation
at the source!

Years of medical studies now suggest that a diet high in antioxidant ACNs significantly reduces joint pain.13

What’s more, scientists are abuzz with the results of recent laboratory studies confirming that ACNs help solve the cause of joint pain and…

As one excited scientist in The Journal of Natural Products reported17

“ACNs inhibit pro-inflammatory cytokines (like COX-2)”
by interrupting the pain pathway…

When you block the pain pathway, it’s like putting a roadblock in the middle of a highway to stop a bad guy from driving through. The bad guy, your pain, is stopped in its tracks before it can start.

In fact, research suggests that ACNs work in nearly the same way as COX-2 blocking drugs, but with one MAJOR ADVANTAGE…

They suppress cell signaling at the root cause
of inflammation and pain!

A study published in the journal Mediators of Inflammation reveals that ACNs inhibit the activity of many different pro-inflammatory cytokines.

They block everything from COX-2 to lesser known pain-causing chemicals like IL-1, MCP-1, even TNF-alpha, by suppressing cell signaling to NF-kB. This is HUGE news…

…because NF-kB is the protein that creates virtually every inflammatory chemical in your body!18

That’s what I call stopping pain and inflammation at its source! At long last…

You can say GOODBYE to your WORST PAIN!
It’s medically proven…

And it’s only the beginning…

….ACNs are also scientifically documented to block the pain protein iNOS…
 
This inflammatory protein causes chronic swelling and pain in joint and cartilage tissue, and let me tell you, iNOS is truly evil. 19

Patients who suffer from the worst chronic joint pain have been shown to have a 35-fold increase in iNOS in the synovial fluid surrounding their joints, compared to patients suffering minor aches and pains of aging!20

In other words, the worse your pain, the higher your levels of iNOS.

This is even BIGGER news!

And not just because blocking iNOS can restore stiff, aching joints back to pain-free flexibility, but also because  blocking iNOS is perhaps…

The #1 Way to STOP FUTURE PAIN and protect your body against aging!

You see, iNOS is not just involved in the formation of pain, it’s also an underlying trigger for chronic inflammation throughout your entire body.

That’s right. iNOS is linked to severe joint trouble, memory loss, heart trouble, and high blood sugar.  It’s even nervous system disorders associated with aging!21

iNOS is nasty stuff, and when you can stop it you feel better and your health grows stronger from head to toe. It’s that simple.

All of this research is staggering. The even bigger surprise?  Native American medicine men seemed to know this intuitively. Their pain-relieving SECRET…

The aronia berry is the richest source
of pain-relieving, body-repairing ACN’s
known to the human race!

Scientific research shows that aronia berries have the highest concentration of pain-killing ACNs… almost four times that of blueberries and five times that of cherries.

In clinical research conducted by the United States Department of Agriculture, 100 foods were screened for ACNs, and only 24 were found to include this unique antioxidant! The other 76 foods had no ACNs at all.

More impressive ...

The study discovered that aronia berries are packed with 2,147 mg of ACN per serving, which is almost four times more than any other food the scientists screened!

When Fox News heard about the study, they called the aronia berry “The King Kong of antioxidant berries.”

Now I know what you’re wondering…

Why have you never heard
of the aronia berry?

Why haven’t you seen it lined up in little plastic containers in your grocery store produce section?

The reason is simple…

Aronia berries taste terrible.

The early American settlers called them… “chokeberries!”

While many natural doctors will still recommend the juice for joint pain, aronia juice isn’t something you want to drink every morning. Believe me, I know.

When I learned about these exciting results, the first thing I did was try aronia juice.  It tasted awful, and I couldn’t stick with it.

However, I had such great results in such a short time from aronia that I got with my team of researchers at Green Valley Natural Solutions to bring you the amazing pain relieving, health-building power of the aronia berry in a supplement.

I’m thrilled to say that TheraFlex ACN has already helped people all over the United States relieve their worst joint pain…

Just ask Dana of Ipswich, MA who tried TheraFlex ACN and emailed me to say:

“What a difference in my pain,
for my wife too!”

“I have been using it for less than a month and usually taking just one pill a day. Not the recommended 2 pills a day…

“…In spite of that fact, I have noticed substantial pain relief from what would have been my normal daily aches and pains from sports related injuries growing up and now, as an adult of retirement age, being an owner and caretaker of horses from all the hard work of lifting and carrying bags of grain and large bales of hay into the barn and up the stairs to the loft above.

“My wife has also been taking it and I recently asked her what she thought. She noticed that her hands felt better ....definitely less arthritic pain. The bottom line.......it has made a noticeable difference for both of us. I think you've got a winner here! Thank you!”

Or there’s Lisa B. who wrote…

“Eased the throbbing and made it easier to move!”

“At times the pain was so bad I would not be able to think straight or do daily tasks. Within days TheraFlex ACN eased the throbbing and made it much easier to move. My joints and muscles feel much looser and I can achieve most of my daily tasks without constant pain!”

Now it’s your turn to put inflammation
and pain behind you
and never give it another thought

TheraFlex ACN can help make your body pain free and flexible, too, because it goes to the source by blocking the pain pathway.

Think about that… virtually all pain—whether from injury, illness or age— happens from a complex pathway of cell signaling that results in those darn inflammatory chemicals causing you to hurt.

No cell signaling on the pain pathway means no inflammatory chemicals and no pain. It’s as simple as that.

As you’ve seen, our TheraFlex ACN users are already experiencing remarkable levels of relief from chronic inflammation and pain. For some it happened within minutes, others in a matter of days or weeks.

What does this mean
for you?

Joint comfort and flexibility like you’ve never enjoyed before.

Plain and simple.

Imagine how having comfortable, flexible joints would change your life…

Walking, sitting or bending over suddenly becomes effortless. You find a new spring in your step and new enjoyment in every day whether you’re working or playing…

Shopping, traveling and events with family take on new meaning when you no longer feel like a burden, and you don’t have to “sit this one out” while everyone else joins in the fun…

Just picture yourself moving more quickly and easily. Feeling stronger and more energetic.

You know you’re feeling good, and now everyone else can see it!

Don’t be surprised if friends and family start asking what you’re doing differently because you look so healthy and happy.

 As one aronia user put it…

“Now that I don’t have constant pain, I have a different point of view where everything seems easier for me to do and I am happier!”

What’s even more exciting, when you stop inflammation at the source you bring on other positive changes to your health.

Remember, long-term inflammation is not good for your joints or any part of your body.

Dr. Fred Pescatore, one of the most sought-after natural physicians in the country and author of the New York Times best-selling book, The Hamptons Diet recently said…

"I truly do believe that probably 7 out of the top 10 leading causes of death in this country are directly attributable to inflammation.” 

Failing memory, bad digestion, declining vision, high cholesterol, poor circulation, frequent infections – they’re ALL related to chronic inflammation!

You shouldn’t accept inflammation as part of “normal aging”.

And finally, thanks to TheraFlex ACN, you don’t have to.

TheraFlex ACN was created specifically to help you address long-term, chronic inflammation, pain and stiffness. The Green Valley team created it specifically because we know so few people are taking advantage of this powerful pain reliever.

There are hundreds of formulas available with many different, “superstar” ingredients such as curcumin.

BUT almost NONE of these formulas have aronia berry’s important pain-fighting discovery – anthocyanins (ACNs).

If you don’t take TheraFlex ACN, you’re probably missing this powerful ingredient that can help you conquer pain!

I speak from experience... 

I take several natural anti-inflammatories, including fish oil, curcumin and boswellia. Even so, I found aronia berry took me to a new level when it comes to pain relief.

I recommend combining it with whatever else you’re doing now – and see for yourself.          

The fact is, you need powerful inflammation fighting at the cellular level to help you get rid of pain once and for all. 

I’m so confident that TheraFlex ACN will help you feel so much better, I’ve arranged for you to try it now and pay for it later if it meets your expectations. You be the judge.  You don’t have to pay for it until 30 days from now – and only if you find it’s everything I’ve said it is.

Don’t wait any longer ...

…Set yourself free
from pain, swelling and stiffness!

You won’t get the extract of the aronia berry in this kind of potency from any other source.  I personally made sure the dose is strong enough to do the job – the kind of dose that produced results in the best clinical studies.

Some TheraFlex ACN users report relief in as little as 20 minutes. For others, it takes a couple days or weeks to bring your painful joints and tissues back to normal and help relieve your pain, swelling and stiffness.

Once you try it, I truly believe you’ll experience soothing relief from pain just about anywhere you’ve got it. 

TheraFlex ACN with aronia berry is a 100% all-natural, and 100% safe product with NO side effects or harmful ingredients. So I guarantee you one thing for sure. . .

With TheraFlex ACN you won’t see
the many dangerous and negative effects
common to pain products

No more worries about the common side effects of over-the-counter pain relievers – ulcers, bleeding, or damage to the heart, liver, and other organs.

In fact, just the opposite… your digestion… your heart and lungs… your brain will grow stronger and healthier as inflammation is quieted in your body.  

With TheraFlex ACN you can rest assured you’re taking the purest, safest, and most highly recognized aronia berry remedy available anywhere.

Because I’m so sure that TheraFlex ACN will help you… and because I want to make this natural breakthrough affordable to anyone who needs it…

I’m making you a “no-strings-attached” offer. . .

Right now—and only from this page—you can try out THERAFLEX ACN for a full 30 days with ZERO RISK! Just pay $9.95 to cover shipping and handling and I’ll rush you a full 60-day supply with no obligation whatsoever.

Our Ironclad, No-Excuses Guarantee

You’ll get two bottles (a 60-day supply) of THERAFLEX ACN—a $79.90 value—with only $9.95 due today for shipping and handling. If for any reason – or no reason at all – you’re not absolutely thrilled with your results by day 30…

(a) Call or email us and let us know.

(b) Then simply send back the unused portion of the product.

(c) We will never charge your card another penny! Your card will only be charged if you decide to keep your purchase beyond 30 days!

This is a 100% ironclad guarantee, so you can’t possibly lose.

I have enough confidence in TheraFlex ACN to take a chance and send you a 60-day supply for nothing today except shipping and handling.

I realize I’m taking a chance here – yet once you try TheraFlex ACN for yourself…

I Know You’ll Understand Exactly
Why I’m so Confident!

The amazing, pain-killing compound in TheraFlex ACN makes other relief formulas look like they’re “a few cards short of a full deck” as a friend of mine used to say.

If the powerful ACNs in TheraFlex ACN aren’t part of your plan to get pain out of your life, you’re missing a vital ingredient.

Just fair warning, though: I can only guarantee you access to this special introductory offer until our current inventory of TheraFlex ACN™ runs out –and when that happens, this extremely generous offer to try it now and pay later may disappear without notice.

So to guarantee you receive the absolute best value –and a chance to experience the amazing benefits of pure, pain-clobbering aronia berry extract while paying nothing today except the low cost of shipping and handling…

Click here to go straight to the secure checkout page and claim your risk-free trial of TheraFlex ACN right now.

Don’t worry – your order information is safe and secure because we protect your credit card and your privacy from start to finish with the same online security system used by trusted companies like Amazon.com.

Once again, I can’t emphasize enough that you must act right now, today, to claim this risk-free trial offer.

Then you’ll discover what thousands already know. . .

TheraFlex ACN’s twice-a-day, easy-to-swallow capsules are rapidly absorbed and speed throughout your system to bring you fast relief.

In short order, you’ll join the thousands of EX-pain sufferers across the USA who now enjoy a strong, flexible, pain-free body.

Just as the Native American medicine men knew hundreds of years ago, aronia berries are a genuine miracle of nature! 

If you battle daily pain, I don’t know of a natural, do-it-yourself solution better than TheraFlex ACN to help you move easier, laugh more, sleep better and get more out of life.

Of course, you could round up your own supply of fresh “chokeberries” and eat hundreds of them to experience the same benefits.  (As I said earlier, they don’t taste very good. . .) 

Or you can do it the easy way – the smart way.  You can simply reply now for TheraFlex ACN and get the pain-killing power of a potent serving of aronia berries concentrated into each capsule.

I give you my personal guarantee that you will be delighted with your results – or your card won’t be charged as long as you let us know within 30 days.

You, too, can enjoy all the benefits of TheraFlex ACN with complete confidence, no matter what your age, and no matter what other pain relief remedies you may be taking.  TheraFlex ACN can help you quickly feel better than you have in years.

Don’t wait! Click here now to get your own supply of TheraFlex ACN — 100% Risk Free!

Yours for Great Health,

Lee Euler

President

Green Valley Natural Solutions

P.S. Let all-natural TheraFlex ACN give you the pain relief you need! Click now if you’re in pain! You’ll get real, lasting relief from discomfort. TheraFlex ACN is effective and COMPLETELY SAFE.  Remember, it’s been shown to have the same kind of COX-fighting-action as pain drugs, without the side effects! Plus, it fights a long list of other INFLAMMATORY COMPOUNDS, too.

Right now—and only from this page—you can try out THERAFLEX ACN for a full 30 days with ZERO RISK! Just pay $9.95 to cover shipping and handling and I’ll rush you a full 60-day supply with no obligation whatsoever.

Our Ironclad, No-Excuses Guarantee

You’ll get two bottles (a 60-day supply) of THERAFLEX ACN—a $79.90 value—with only $9.95 due today for shipping and handling. If for any reason – or no reason at all – you’re not absolutely thrilled with your results by day 30…

(a) Call or email us and let us know.

(b) Then simply send back the unused portion of the product.

(c) We will never charge your card another penny! Your card will only be charged if you decide to keep your purchase beyond 30 days!

This is a 100% ironclad guarantee, so you can’t possibly lose.

1 - Hämäläinen M., et al. Anti-Inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007; doi: 10.1155/2007 /45673.

2 - Who Were The First Americans, by Stefan Lovgren  for National Geographic, September 3, 2004. ttp://news.nationalgeographic.com/news/2003/09/0903_030903_bajaskull.html

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Hämäläinen M., et al. Anti-Inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007; doi: 10.1155/2007 /45673.

15 - Naruszewicz M,et al. Combination therapy of statin with flavonoids rich in extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atherosclerosis. 2007; 194: e179-e184.Federation of American Societies for Experimental Biology.  Chokeberry extract found to regulate weight gain, blood glucose, and inflammation in rats.  Science Daily, July 24, 2010.  Retrieved from http://www.sciencedaily.com

16 - Appel K, et al., Chokeberry (Aronia melanocarpa (Michx.) Elliot) concentrate inhibits NF-κB and synergizes with selenium to inhibit the release of pro-inflammatory mediators in macrophages. Fitoterapia. 2015 Sep;105:73-82. doi: 10.1016/j.fitote.2015.06.009. Epub 2015 Jun 14.

17 - Wang H., et al. Antioxidant and anti-inflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J. Nat. Prod.1999; 62: 294–296.
Pergola C., et al. Inhibition of nitric oxide biosynthesis by anthocyanin fraction of
blackberry extract. Nitric Oxide 2006; 15: 30-39.

18 - Hämäläinen M., et al. . Anti-Inflammatory effects of flavonoids: genistein,
kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007; doi: 10.1155/2007 /45673.

19 - Hämäläinen M., et al. . Anti-Inflammatory effects of flavonoids: genistein,
kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007; doi: 10.1155/2007 /45673.

20 - Farrell AJ, Blake DR, Palmer RMJ, Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis. 1992;51:1219–22.

90. Ueki Y, et al. Increased nitric oxide levels in patients with rheumatoid arthritis. J Rheumatol. 1996;23:230–6.

21 - K-D Kröncke, et al. Inducible nitric oxide synthase in human diseases. Clin Exp Immunol. 1998 Aug; 113(2): 147–156.

22 - C. Chrubasik, The Clinical Effectiveness of Chokeberry : A Systematic Review.
Phytother Res. 2010 Aug;24(8):1107-14. doi: 10.1002/ptr.3226.

23 - C. Chrubasik, The Clinical Effectiveness of Chokeberry : A Systematic Review.
Phytother Res. 2010 Aug;24(8):1107-14. doi: 10.1002/ptr.3226.

24 - Naruszewicz M, et al. Combination therapy of statin with flavonoids rich in extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atherosclerosis. 2007; 194: e179-e184.